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推荐稀释比 ： ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
组成 ： Phosphate-buffered solution
纯化工艺 ： Recombinant Expression and Affinity purified
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： Please check the information on the tube
克隆性 ： Monoclonal
克隆号 ： PTR1381
抗原&靶点信息
特异性 ： This recombinant monoclonal antibody can detects endogenous levels of CD284 protein.
基因名称 ： TLR4
蛋白名称 ： Toll-like receptor 4
别名 ： TLR4;Toll-like receptor 4;hToll;CD antigen CD284
背景：
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
细胞定位 ： Cell membrane ; Single-pass type I membrane protein . Early endosome . Cell projection, ruffle . Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584). Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation. .
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