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推荐稀释比 ： WB 1:500-2000;IF/ICC1:50-200;ELISA 1:2000-20000;IHC 1:50-200
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： This antibody detects endogenous levels of Human,Mouse,Rat ITGA3 (heavy chain, Cleaved-Phe33, protein was cleaved amino acid sequence between 32-33 )
基因名称 ： ITGA3 MSK18
蛋白名称 ： ITGA3 (heavy chain, Cleaved-Phe33)
别名 ： Integrin alpha-3;CD49 antigen-like family member C;FRP-2;Galactoprotein B3;GAPB3;VLA-3 subunit alpha;CD antigen CD49c;[Cleaved into: Integrin alpha-3 heavy chain;Integrin alpha-3 light chain]
背景：
integrin subunit alpha 3(ITGA3) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015],
细胞定位 ： Cell membrane ; Single-pass type I membrane protein . Cell membrane ; Lipid-anchor . Cell projection, invadopodium membrane ; Single-pass type I membrane protein . Cell projection, filopodium membrane ; Single-pass type I membrane protein . Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. .
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