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货号: PH0626
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: CREBBP
应用: WB,IF,ELISA
反应性 : Human,
宿主物种 : Mouse
MW(CalcμLated) : 266kD
MW(Observed): 266kD
同种型-Isotype : IgG2b,Kappa
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein G
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Monoclonal
克隆号 : PT0619
抗原&靶点信息
特异性 : This antibody detects endogenous levels of CREBBP protein.
基因名称 : CREBBP CBP
蛋白名称 : CREB-binding protein (EC 2.3.1.48)
别名 : CREBBP;CBP;CREB-binding protein
背景:
CREB binding protein(CREBBP) Homo sapiens This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations invo


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