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货号: PH1347
货期: 一周
价格: 100μL/2200
所属分类:
靶点: PP2B-Aα
应用: WB
反应性 : Human,Mouse,Rat
宿主物种 : Mouse
MW(CalcμLated) : 59kD
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000-1:2000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : Affinity purification
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
抗原&靶点信息
特异性 : PP2B-Aα Monoclonal Antibody detects endogenous levels of PP2B-Aα protein.
基因名称 : PPP3CA
蛋白名称 : Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
别名 : PP2B-Aα;PPP3CA;CALNA;CNA;Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;CAM-PRP catalytic subunit;Calmodulin-dependent calcineurin A subunit alpha isoform
背景:
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 Fe(3+) ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.,online information:Calcineurin entry,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-2B subfamily.,subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.,subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.,


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