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推荐稀释比 ： ELISA 1:5000-100000
组成 ： Phosphate-buffered solution
来源 ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 ： Recombinant Expression and Affinity purified
储存 ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 ： Please check the information on the tube
克隆性 ： Monoclonal
克隆号 ： PN0161
抗原&靶点信息
特异性 ： This recombinant monoclonal antibody can detects endogenous levels of HLA-DRA protein.
基因名称 ： HLA-DRA HLA-DRA1
蛋白名称 ： C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185)
别名 ： BLR1;MDR15;BLR 1 antibody;BLR1 antibody;Burkitt lymphoma receptor 1 antibody;Burkitt lymphoma receptor 1 GTP binding protein antibody;Burkitt lymphoma receptor 1;GTP binding protein;chemokine;C-X-C motif;receptor 5;antibody;C X C chemokine receptor type 5 antibody;C-X-C chemokine receptor type 5 antibody;CD 185 antibody;CD185 antibody;CD185 antigen antibody;Chemokine;C-X-C motif;receptor 5 antibody;Chemokine C X C motif receptor 5 antibody;Chemokine CXC motif receptor 5 antibody;Chemokine receptor 5 antibody;CXC chemokine receptor type 5 antibody;CXC R5 antibody;CXC-R5 antibody;CXCR 5 antibody;CXCR-5 antibody;Cxcr5 antibody;CXCR5_HUMAN antibody;MDR 15 antibody;MDR-15 antibody;MDR15 antibody;MGC117347 antibody;Monocyte derived receptor 15 antibody;Monocyte-derived receptor 15 antibody;
背景：
HLA-DRA is one of the HLA class II alpha chain paralogues.This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]
细胞定位 ： Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Autolysosome membrane ; Single-pass type I membrane protein. The MHCII complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:9075930, PubMed:18305173). Component of immunological synapses at the interface between T cell and APC (PubMed:15322540, PubMed:29884618). .
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