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货号: PH0691
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: AKT1/2/3
应用: WB,IP,IF,ELISA
反应性 : Human,Mouse,Rat,
宿主物种 : Mouse
MW(Observed): 60kD
同种型-Isotype : IgG3,Kappa
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein G
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Monoclonal
克隆号 : PTR2314
抗原&靶点信息
特异性 : This antibody detects endogenous levels of Akt 1/2/3 protein.
基因名称 : AKT1/AKT2/AKT3
蛋白名称 : RAC-alpha serine/threonine-protein kinase;RAC-beta serine/threonine-protein kinase;RAC-gamma serine/threonine-protein kinase
别名 : AKT1
数据库链接:
背景:
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]


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