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货号: PG3336
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: TLR2
应用： IHC,IF
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： IHC 1:200-500;IF 1:50-200
组成 ： PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： The antibody detects endogenous TLR2 protein.
基因名称 ： TLR2
蛋白名称 ： Toll-like receptor 2
别名 ： TLR2;TIL4;Toll-like receptor 2;Toll/interleukin-1 receptor-like protein 4;CD282
背景：
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
细胞定位 ： Membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein . Membrane raft . Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers. .
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