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HLA-DPα1 Polyclonal Antibody

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说明书下载
货号: PD5341
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: HLA-DPα1
应用: WB,ELISA
反应性 : Human
宿主物种 : Rabbit
MW(Observed): 29kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : HLA-DPα1 Polyclonal Antibody detects endogenous levels of HLA-DPα1 protein.
基因名称 : HLA-DPA1
蛋白名称 : HLA class II histocompatibility antigen DP alpha 1 chain
别名 : HLA-DPA1;HLA-DP1A;HLASB;HLA class II histocompatibility antigen;DP alpha 1 chain;DP;W3;DP;W4;HLA-SB alpha chain;MHC class II DP3-alpha;MHC class II DPA1

数据库链接:

Organism

基因 ID

SwissProt

背景:

HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008],

细胞定位 : Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

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