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货号: PH0890
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: HER2
应用： WB,IF,IHC
反应性 ： Human,Mouse,Rat
宿主物种 ： Mouse
MW(Observed)： 180kD
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:2000-4000;IHC 1:200;IF 1:200
组成 ： PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺 ： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
克隆号 ： 11H9
抗原&靶点信息
特异性 ： The antibody detects endogenous ErbB-2/HER-2 proteins.
基因名称 ： ERBB2
蛋白名称 ： Receptor tyrosine-protein kinase erbB-2
别名 ： ERBB2;HER2;MLN19;NEU;NGL;Receptor tyrosine-protein kinase erbB-2;Metastatic lymph node gene 19 protein;MLN 19;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD340
背景：
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d
细胞定位 ： [Isoform 1]: Cell membrane ; Single-pass type I membrane protein. Early endosome . Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). .; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.
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