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MLK3 (phospho Ser674) Polyclonal Antibody

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货号: PF0718
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: MLK3
应用: WB,IHC
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 93kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:500-2000;IHC 1:50-300
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : Phospho-MLK3 (S674) Polyclonal Antibody detects endogenous levels of MLK3 protein only when phosphorylated at S674.
基因名称 : MAP3K11
蛋白名称 : Mitogen-activated protein kinase kinase kinase 11
别名 : MAP3K11;MLK3;PTK1;SPRK;Mitogen-activated protein kinase kinase kinase 11;Mixed lineage kinase 3;Src-homology 3 domain-containing proline-rich kinase

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008],

细胞定位 : Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Location is cell cycle dependent.

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