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货号: PH1191
货期: 一周
价格: 100μL/2200
所属分类：
靶点: DDB1
应用： WB
反应性 ： Human,Mouse,Rat,Monkey
宿主物种 ： Mouse
MW(Observed)： 127kD
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
抗原&靶点信息
特异性 ： This antibody detects endogenous levels of DDB1 and does not cross-react with related proteins.
基因名称 ： ddb1
别名 ： Damage specific DNA binding protein 1;Damage-specific DNA-binding protein 1;DDB 1;DDB p127 subunit;Ddb1;DDB1_HUMAN;DDBa;DNA damage binding protein 1;DNA damage-binding protein 1;DNA damage-binding protein a;HBV X-associated protein 1;UV damaged DNA binding factor;UV damaged DNA binding protein 1;UV DDB 1;UV DDB1;UV-damaged DNA-binding factor;UV-damaged DNA-binding protein 1;UV-DDB 1;UV-DDB1;X associated protein 1;XAP 1;XAP-1;XAP1;Xeroderma pigmentosum group E complementing protein;Xeroderma pigmentosum group E-complementing protein;XPCE;XPE;XPE BF;XPE binding factor;XPE-BF;XPE-binding factor.
背景：
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecul
细胞定位 ： Cytoplasm . Nucleus . Primarily cytoplasmic (PubMed:10777491, PubMed:11673459). Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage (PubMed:10777491, PubMed:11673459). .
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