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货号: PH0689
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
应用: WB,IHC-p,IF(paraffin section)
反应性 : Human,Rat,Mouse
宿主物种 : Mouse
MW(Observed): 17、32
隐藏域元素占位
详细信息
推荐稀释比 : WB: 500-2000;IHC 1:100-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存 : -20°C/1 year
浓度 : 1 mg/ml
克隆性 : Monoclonal
克隆号 : 5H10
抗原&靶点信息
特异性 : Caspase-3 protein detects endogenous levels of CASP3
基因名称 : CASP3
蛋白名称 : Caspase3
别名 : CASP3
背景:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],


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