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推荐稀释比 ： WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
组成 ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 ： Protein G
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Monoclonal
克隆号 ： PTR1364
抗原&靶点信息
特异性 ： This antibody detects endogenous levels of STAT3.
基因名称 ： STAT3
蛋白名称 ： Signal transducer and activator of transcription 3 (Acute-phase response factor)
别名 ： STAT3;APRF;Signal transducer and activator of transcription 3;Acute-phase response factor
背景：
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper
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