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货号: PH1375
货期: 一周
价格: 100μL/2200
所属分类：
靶点: HDAC4
应用： WB
反应性 ： Human,Mouse,Rat
宿主物种 ： Mouse
MW(CalcμLated) ： 119kD
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000-1:2000;Not yet tested in other applications.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： Affinity purification
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
抗原&靶点信息
特异性 ： HDAC4 Monoclonal Antibody detects endogenous levels of HDAC4 protein.
基因名称 ： HDAC4
蛋白名称 ： Histone deacetylase 4
别名 ： HDAC4;KIAA0288;Histone deacetylase 4;HD4
背景：
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008],
细胞定位 ： Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity). .
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