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货号: PH0655
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: p40/p63
应用: WB,IHC
反应性 : Human,Mouse,Rat
宿主物种 : Mouse
MW(Observed): 50-80kD
隐藏域元素占位
详细信息
推荐稀释比 : IHC 1:50-200;WB 1:500-2000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Monoclonal
克隆号 : 3F11
抗原&靶点信息
特异性 : This antibody detects endogenous levels of human P63-α
基因名称 : TP63 KET P63 P73H P73L TP73L
蛋白名称 : P63-α
别名 : Tumor protein 63;p63;Chronic ulcerative stomatitis protein;CUSP;Keratinocyte transcription factor KET;Transformation-related protein 63;TP63;Tumor protein p73-like;p73L;p40;p51;
背景:
tumor protein p63(TP63) Homo sapiens This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrim


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