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货号: PH0696
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: Stat1
应用： IHC,IF
反应性 ： Human,Rat,Mouse
宿主物种 ： Mouse
MW(Observed)： 84,91kD
隐藏域元素占位
详细信息
推荐稀释比 ： IHC 1:100-200;IF 1:50-200
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Monoclonal
克隆号 ： 8H11
抗原&靶点信息
特异性 ： STAT1 protein detects endogenous levels of STAT1
基因名称 ： STAT1
蛋白名称 ： Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
别名 ： STAT1;Signal transducer and activator of transcription 1-alpha/beta;Transcription factor ISGF-3 components p91/p84
背景：
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008],
细胞定位 ： Cytoplasm . Nucleus . Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 (PubMed:15322115). Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus (PubMed:28753426). Translocates into the nucleus in response to interferon-beta stimulation (PubMed:26479788). .
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