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推荐稀释比 ： ELISA 1:5000-100000
组成 ： Phosphate-buffered solution
来源 ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 ： Recombinant Expression and Affinity purified
储存 ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 ： Please check the information on the tube
克隆性 ： Monoclonal
克隆号 ： PN0354
抗原&靶点信息
特异性 ： This recombinant monoclonal antibody can detects endogenous levels of CD166 protein.
基因名称 ： ALCAM MEMD
蛋白名称 ： Epithelial cell adhesion molecule
别名 ： 17 1A;323/A3;Adenocarcinoma associated antigen;Adenocarcinoma-associated antigen;Antigen identified by monoclonal antibody AUA1;AUA1;CD326;CD326 antigen;Cell surface glycoprotein Trop 1;Cell surface glycoprotein Trop 2;Cell surface glycoprotein Trop-1;CO 17A;CO17 1A;CO17A;DIAR5;EGP 2;EGP;EGP2;EGP314;EGP40;Ep CAM;Ep-CAM;EPCAM;EPCAM_HUMAN;Epithelial cell adhesion molecule;Epithelial Cell Adhesion Molecule Intracellular Domain;EpCAM-ICD;Epithelial cell surface antigen;Epithelial cellular adhesion molecule;Epithelial glycoprotein 1;Epithelial glycoprotein 314;Epithelial glycoprotein;ESA;GA733 1;GA733 2;GA733-2;gastrointestinal tumor-associated antigen 2;35-KD glycoprotein;hEGP 2;hEGP314;HNPCC8;Human epithelial glycoprotein 2;KS 1/4 antigen;KS1/4;KSA;Lymphocyte antigen 74;M1S 1;M1S2;M4S1;Major gastrointestinal tumor associated protein GA733 2;Major gastrointestinal tumor-associated protein GA733-2;Membrane component chromosome 4 surface marker;35kD glycoprotein;Membrane component;chromosome 4;surface marker 1;Membrane component;chromosome 4;surface marker;MIC18;MK 1;TACD1;TACSTD1;TROP1;Tumor associated calcium signal transducer 1;Tumor associated calcium signal transducer 2 precursor;Tumor-associated calcium signal transducer 1;CD326 nanobody;EPCAM nanobody;
背景：
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain.This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]
细胞定位 ： Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938). .; [Isoform 3]: Secreted .
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