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货号: PD4182
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: PAK5/6
应用： WB,ELISA
反应性 ： Human,Mouse
宿主物种 ： Rabbit
MW(Observed)： 75kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： PAK5/6 Polyclonal Antibody detects endogenous levels of PAK5/6 protein.
基因名称 ： PAK6/PAK7
蛋白名称 ： Serine/threonine-protein kinase PAK 6/7
别名 ： PAK7;KIAA1264;PAK5;Serine/threonine-protein kinase PAK 7;p21-activated kinase 5;PAK-5;p21-activated kinase 7;PAK-7;PAK6;PAK5;Serine/threonine-protein kinase PAK 6;PAK-5;p21-activated kinase 6;PAK-6
数据库链接：
背景：
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],
细胞定位 ： Mitochondrion. Cytoplasm. Nucleus. Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
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