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SARM1 Polyclonal Antibody

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说明书下载
货号: PG6258
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: SARM1
应用: WB,ELISA
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 79kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-2000;ELISA 1:5000-20000
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : SARM1 Polyclonal Antibody detects endogenous levels of protein.
基因名称 : SARM1 KIAA0524 SAMD2 SARM
蛋白名称 : Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Sterile alpha motif domain-containing protein 2) (SAM domain-containing protein 2) (Tir-1 homolog)

数据库链接:

Organism

基因 ID

SwissProt

Mouse
背景:

caution:Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method.,function:Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.,similarity:Contains 1 TIR domain.,similarity:Contains 2 SAM (sterile alpha motif) domains.,subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function.,tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.,

细胞定位 : Cytoplasm . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse . Mitochondrion . Associated with microtubules. .

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