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货号: PD2855
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: CYP2A6/7/13
应用： WB,ELISA
反应性 ： Human
宿主物种 ： Rabbit
MW(Observed)： 56kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： CYP2A6/7/13 Polyclonal Antibody detects endogenous levels of CYP2A6/7/13 protein.
基因名称 ： CYP2A6/CYP2A7/CYP2A13
蛋白名称 ： Cytochrome P450 2A6/Cytochrome P450 2A7/Cytochrome P450 2A13
别名 ： CYP2A6;CYP2A3;Cytochrome P450 2A6;1,4-cineole 2-exo-monooxygenase;CYPIIA6;Coumarin 7-hydroxylase;Cytochrome P450 IIA3;Cytochrome P450;I;CYP2A7;Cytochrome P450 2A7;CYPIIA7;Cytochrome P450 IIA4;CYP2A13;Cytochrome P450 2A13;CYPIIA13
数据库链接：
背景：
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008],
细胞定位 ： Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
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