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货号: PG5481
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: DSE
应用: WB
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 105kD
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-2000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : This antibody detects endogenous levels of DSE at Human/Mouse
基因名称 : DSE SART2
蛋白名称 : DSE
别名 : Dermatan-sulfate epimerase;DS epimerase;Chondroitin-glucuronate 5-epimerase;Squamous cell carcinoma antigen recognized by T-cells 2;SART-2;
背景:
The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016],


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