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11β-HSD1 Polyclonal Antibody

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说明书下载
货号: PD2474
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
+


靶点: 11β-HSD1
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(Observed): 35kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : 11β-HSD1 Polyclonal Antibody detects endogenous levels of 11β-HSD1 protein.
基因名称 : HSD11B1
蛋白名称 : Corticosteroid 11-beta-dehydrogenase isozyme 1
别名 : HSD11B1;HSD11;HSD11L;Corticosteroid 11-beta-dehydrogenase isozyme 1;11-beta-hydroxysteroid dehydrogenase 1;11-DH;11-beta-HSD1

数据库链接:

Organism

基因 ID

SwissProt

背景:

hydroxysteroid 11-beta dehydrogenase 1(HSD11B1) Homo sapiens The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011],

细胞定位 : Endoplasmic reticulum membrane ; Single-pass type II membrane protein .

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