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货号: PH1192
货期: 一周
价格: 100μL/2200
靶点: ALDH2
应用: WB
反应性 : Human,Mouse,Rat,Monkey,Hamster
宿主物种 : Mouse
MW(Observed): 56kD
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
抗原&靶点信息
特异性 : This antibody detects endogenous levels of ALDH2 and does not cross-react with related proteins.
基因名称 : aldh2
蛋白名称 : Aldehyde dehydrogenase mitochondrial
别名 : ALDH2;ALDM;Aldehyde dehydrogenase, mitochondrial;ALDH class 2;ALDH-E2;ALDHI
背景:
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform,


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