信号通路

联系我们

15392937510

地址:湖北省武汉市江夏区神墩四路 666 号武汉国英种业大厦A栋14F 
邮箱:pinuofei2017@163.com
TEL:15392937510

WWOX Polyclonal Antibody

复制产品信息

说明书下载
货号: PD3020
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
undefined
+
  • undefined

所属分类:


靶点: WWOX
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 47kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : WWOX Polyclonal Antibody detects endogenous levels of WWOX protein.
基因名称 : WWOX
蛋白名称 : WW domain-containing oxidoreductase
别名 : WWOX;FOR;WOX1;WW domain-containing oxidoreductase;Fragile site FRA16D oxidoreductase

数据库链接:

Organism

基因 ID

SwissProt

背景:

WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.

细胞定位 : Cytoplasm . Nucleus . Mitochondrion . Golgi apparatus . Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus. .

推荐产品

相关文献

留言咨询

留下您想咨询的信息,我们会尽快联系您

提交