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TRAP230 Polyclonal Antibody

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说明书下载
货号: PD3195
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: TRAP230
应用: IHC,IF,WB,ELISA
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(CalcμLated) : 247kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : TRAP230 Polyclonal Antibody detects endogenous levels of TRAP230 protein.
基因名称 : MED12
蛋白名称 : Mediator of RNA polymerase II transcription subunit 12
别名 : MED12;ARC240;CAGH45;HOPA;KIAA0192;TNRC11;TRAP230;Mediator of RNA polymerase II transcription subunit 12;Activator-recruited cofactor 240 kDa component;ARC240;CAG repeat protein 45;Mediator complex subunit 12;OPA-containing prote

数据库链接:

Organism

基因 ID

SwissProt

Mouse
背景:

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009],

细胞定位 : Nucleus .

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