产品服务
信号通路
货号: PD4210
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: p35
应用： WB,IHC,IF,ELISA
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(Observed)： 38kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： p35 Polyclonal Antibody detects endogenous levels of p35 protein.
基因名称 ： CDK5R1
蛋白名称 ： Cyclin-dependent kinase 5 activator 1
别名 ： CDK5R1;CDK5R;NCK5A;Cyclin-dependent kinase 5 activator 1;CDK5 activator 1;Cyclin-dependent kinase 5 regulatory subunit 1;TPKII regulatory subunit;[Cleaved into: Cyclin-dependent kinase 5 activator 1, p35;p35;Cyclin-dependent kinase 5 activator 1, p25;p25;Tau protein kinase II 23 kDa subunit;p23;]
背景：
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008],
细胞定位 ： [Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell projection, neuron projection . In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. .; [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus . Cytoplasm, perinuclear region . Perikaryon . The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions (PubMed:18507738). In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites (PubMed:18507738). .
推荐产品
相关文献
我们始终开放沟通，期待为您提供支持。
我们以一抗、二抗产品为核心，深耕抗体试剂细分领域。依托自主搭建的核心技术平台与专业的研发生产团队，我们为全球高校、科研院所、生物医药企业等客户提供高可靠性的生物试剂产品及全链条技术
支持服务。自成立以来，Pinofibio 始终坚守“以科研需求为导向”的发展理念，通过完善的研发体系、严苛的质量控制与高效的服务响应，致力于构建覆盖多物种、多靶点的抗体产品矩阵，助力科研工作者攻克技术难题，推动生物医药产业的创新发展。
武汉市皮诺飞生物科技有限公司
地址：湖北省武汉市江夏区神墩四路 666 号武汉国英种业大厦A栋14F
邮箱：pinuofei2017@163.com
TEL：15392937510
小红书
实验服务
公众号
抗体服务
微信客服