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MRCKβ Polyclonal Antibody

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说明书下载
货号: PD4812
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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所属分类:


靶点: MRCKβ
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(Observed): 194kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : MRCKβ Polyclonal Antibody detects endogenous levels of MRCKβ protein.
基因名称 : CDC42BPB
蛋白名称 : Serine/threonine-protein kinase MRCK beta
别名 : CDC42BPB;KIAA1124;Serine/threonine-protein kinase MRCK beta;CDC42-binding protein kinase beta;CDC42BP-beta;DMPK-like beta;Myotonic dystrophy kinase-related CDC42-binding kinase beta;MRCK beta;Myotonic dystrophy protein kinase-like b

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008],

细胞定位 : Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction . Cell projection, lamellipodium . Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42 (PubMed:21240187). Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner (By similarity). .

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