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货号: PD5175
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: IREβ
应用: IHC,IF,ELISA
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(CalcμLated) : 102kD
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : IRE1α/β Polyclonal Antibody detects endogenous levels of IRE1α/β protein.
基因名称 : ERN2
蛋白名称 : Serine/threonine-protein kinase/endoribonuclease IRE2
别名 : ERN2;IRE2;Serine/threonine-protein kinase/endoribonuclease IRE2;Endoplasmic reticulum-to-nucleus signaling 2;Inositol-requiring protein 2;hIRE2p;Ire1-beta;IRE1b
背景:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.,function:Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,


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