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详细信息
推荐稀释比 : WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : FIR Polyclonal Antibody detects endogenous levels of FIR protein.
基因名称 : FARP2
蛋白名称 : FERM RhoGEF and pleckstrin domain-containing protein 2
别名 : FARP2;KIAA0793;PLEKHC3;FERM;RhoGEF and pleckstrin domain-containing protein 2;FERM domain including RhoGEF;FIR;Pleckstrin homology domain-containing family C member 3;PH domain-containing family C member 3
背景:
function:Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 FERM domain.,similarity:Contains 2 PH domains.,subunit:Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding.,


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