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货号: PD5797
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: ERI1
应用: WB,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(Observed): 37kD
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-1:2000;ELISA 1:5000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : ERI1 Polyclonal Antibody detects endogenous levels of ERI1 protein.
基因名称 : ERI1
蛋白名称 : 3'-5' exoribonuclease 1
别名 : ERI1;3'EXO;THEX1;3'-5' exoribonuclease 1;3'-5' exonuclease ERI1;Eri-1 homolog;Histone mRNA 3'-end-specific exoribonuclease;Histone mRNA 3'-exonuclease 1;Protein 3'hExo;HEXO
背景:
cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity.,function:RNA exonuclease that binds to the 3'-end of histone mRNAs and probably degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Required for 5.8S rRNA 3'-end processing.,sequence caution:Translated as Leu.,similarity:Contains 1 exonuclease domain.,similarity:Contains 1 SAP domain.,subunit:Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Requires the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Also binds to 5.8s ribosomal RNA.,


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