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CYP2D6 Polyclonal Antibody

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说明书下载
货号: PD6152
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: CYP2D6
应用: WB,IHC,IF,ELISA
反应性 : Human
宿主物种 : Rabbit
MW(Observed): 55kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : CYP2D6 Polyclonal Antibody detects endogenous levels of CYP2D6 protein.
基因名称 : CYP2D6
蛋白名称 : Cytochrome P450 2D6
别名 : CYP2D6;CYP2DL1;Cytochrome P450 2D6;CYPIID6;Cytochrome P450-DB1;Debrisoquine 4-hydroxylase

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in

细胞定位 : Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein.

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