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ATF-6β Polyclonal Antibody

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说明书下载
货号: PD6854
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560

详细信息

推荐稀释比 : WB 1:500-1:2000;ELISA 1:20000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : ATF-6β Polyclonal Antibody detects endogenous levels of ATF-6β protein.
基因名称 : ATF6B
蛋白名称 : Cyclic AMP-dependent transcription factor ATF-6 beta
别名 : ATF6B;CREBL1;G13;Cyclic AMP-dependent transcription factor ATF-6 beta;cAMP-dependent transcription factor ATF-6 beta;Activating transcription factor 6 beta;ATF6-beta;Protein G13;cAMP response element-binding protein-related protein;

数据库链接:

Organism

基因 ID

SwissProt

Mouse
背景:

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],

细胞定位 : Endoplasmic reticulum membrane ; Single-pass type II membrane protein .; [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. .

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