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货号: PF0175
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: HER4/ErbB4
应用： IHC,WB
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(Observed)： 180kD
隐藏域元素占位
详细信息
修饰-Modification ： Phospho
推荐稀释比 ： WB 1:500-2000;IHC 1:50-200
组成 ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 ： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： This antibody detects endogenous levels of HER4 (Phospho Tyr1242) Rabbit pAb at Human, Mouse,Rat
基因名称 ： ERBB4 HER4
蛋白名称 ： Receptor tyrosine-protein kinase erbB-4 (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
别名 ： ERBB4;HER4;Receptor tyrosine-protein kinase erbB-4;Proto-oncogene-like protein c-ErbB-4;Tyrosine kinase-type cell surface receptor HER4;p180erbB4
背景：
erb-b2 receptor tyrosine kinase 4(ERBB4) Homo sapiens This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008],
细胞定位 ： Cell membrane ; Single-pass type I membrane protein . In response to NRG1 treatment, the activated receptor is internalized.; [ERBB4 intracellular domain]: Nucleus . Mitochondrion . Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus.
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