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货号: PF0752
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: Androgen Receptor
应用： IF,ELISA
反应性 ： Human,Mouse
宿主物种 ： Rabbit
MW(CalcμLated) ： 99kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
修饰-Modification ： Phospho
推荐稀释比 ： IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications;
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： Phospho-AR (S94) Polyclonal Antibody detects endogenous levels of AR protein only when phosphorylated at S94.
基因名称 ： AR
蛋白名称 ： Androgen receptor
别名 ： AR;DHTR;NR3C4;Androgen receptor;Dihydrotestosterone receptor;Nuclear receptor subfamily 3 group C member 4
背景：
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform
细胞定位 ： Nucleus . Cytoplasm . Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. .
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