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AMPKβ1 (phospho Ser182) Polyclonal Antibody

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说明书下载
货号: PF1203
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: AMPKβ1
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse,Rat,Monkey
宿主物种 : Rabbit
MW(Observed): 33kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : Phospho-AMPKβ1 (S182) Polyclonal Antibody detects endogenous levels of AMPKβ1 protein only when phosphorylated at S182.
基因名称 : PRKAB1
蛋白名称 : 5'-AMP-activated protein kinase subunit beta-1
别名 : PRKAB1;AMPK;5'-AMP-activated protein kinase subunit beta-1;AMPK subunit beta-1;AMPKb

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided

细胞定位 : nucleus,nucleoplasm,cytosol,nucleotide-activated protein kinase complex,

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