信号通路

联系我们

15392937510

地址:湖北省武汉市江夏区神墩四路 666 号武汉国英种业大厦A栋14F 
邮箱:pinuofei2017@163.com
TEL:15392937510

FADD (phospho Ser194) Polyclonal Antibody

复制产品信息

说明书下载
货号: PF1289
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
undefined
undefined
+
  • undefined
  • undefined


靶点: FADD
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 28kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : Phospho-FADD (S194) Polyclonal Antibody detects endogenous levels of FADD protein only when phosphorylated at S194.
基因名称 : FADD
蛋白名称 : Protein FADD
别名 : FADD;MORT1;GIG3;Protein FADD;FAS-associated death domain protein;FAS-associating death domain-containing protein;Growth-inhibiting gene 3 protein;Mediator of receptor induced toxicity

数据库链接:

Organism

基因 ID

SwissProt

Mouse
背景:

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008],

细胞定位 : cytoplasm,cytosol,plasma membrane,death-inducing signaling complex,CD95 death-inducing signaling complex,neuron projection,cell body,membrane raft,ripoptosome,

推荐产品

相关文献

留言咨询

留下您想咨询的信息,我们会尽快联系您

提交