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PLC γ1 (phospho Tyr771) Polyclonal Antibody

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说明书下载
货号: PF1310
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : Phospho-PLC γ1 (Y771) Polyclonal Antibody detects endogenous levels of PLC γ1 protein only when phosphorylated at Y771.
基因名称 : PLCG1
蛋白名称 : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
别名 : PLCG1;PLC1;1-phosphatidylinositol 4;5-bisphosphate phosphodiesterase gamma-1;PLC-148;Phosphoinositide phospholipase C-gamma-1;Phospholipase C-II;PLC-II;Phospholipase C-gamma-1;PLC-gamma-1

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

细胞定位 : Cell projection, lamellipodium . Cell projection, ruffle . Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. .

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