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货号: PF1388
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: NFAT4
应用： WB,IHC,IF,ELISA
反应性 ： Human,Mouse
宿主物种 ： Rabbit
MW(Observed)： 115kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
修饰-Modification ： Phospho
推荐稀释比 ： WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： Phospho-NFATc3 (S165) Polyclonal Antibody detects endogenous levels of NFATc3 protein only when phosphorylated at S165.
基因名称 ： NFATC3
蛋白名称 ： Nuclear factor of activated T-cells cytoplasmic 3
别名 ： NFATC3;NFAT4;Nuclear factor of activated T-cells;cytoplasmic 3;NF-ATc3;NFATc3;NFATx;T-cell transcription factor NFAT4;NF-AT4
背景：
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010],
细胞定位 ： Cytoplasm . Nucleus . Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
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