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Rad17 (phospho Ser645) Polyclonal Antibody

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说明书下载
货号: PF1625
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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所属分类:


靶点: Rad17
应用: WB,ELISA,IHC
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 77kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : Phospho-Rad17 (S645) Polyclonal Antibody detects endogenous levels of Rad17 protein only when phosphorylated at S645.
基因名称 : RAD17
蛋白名称 : Cell cycle checkpoint protein RAD17
别名 : RAD17;R24L;Cell cycle checkpoint protein RAD17;hRad17;RF-C/activator 1 homolog

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h

细胞定位 : Nucleus . Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.

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