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Cleaved-Spectrin α II (D1185) Polyclonal Antibody

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说明书下载
货号: PK0239
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: Spectrin α II
应用: WB,ELISA
反应性 : Human,Rat,Mouse,
宿主物种 : Rabbit
MW(Observed): 137kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : Cleaved-Spectrin α II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin α II protein resulting from cleavage adjacent to D1185.
基因名称 : SPTAN1
蛋白名称 : Spectrin alpha chain non-erythrocytic 1
别名 : SPTAN1;NEAS;SPTA2;Spectrin alpha chain;non-erythrocytic 1;Alpha-II spectrin;Fodrin alpha chain;Spectrin, non-erythroid alpha subunit

数据库链接:

Organism

基因 ID

SwissProt

Mouse
背景:

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010],

细胞定位 : Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. .

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