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VAV1 (PT1677R) PT™ Rabbit mAb

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说明书下载
货号: PL0111
货期: 现货
价格: 100μL/1800
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靶点: VAV1
应用: WB,IF,IP,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 98kD
MW(Observed): 98kD
同种型-Isotype : IgG,Kappa

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆号 : Monoclonal

抗原&靶点信息

特异性 : Endogenous
基因名称 : VAV1
蛋白名称 : Proto-oncogene vav
别名 : VAV1;VAV;Proto-oncogene vav

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],

细胞定位 : intracellular,cytosol,plasma membrane,cell-cell junction,

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