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LATS2 (PT1587R) PT™ Rabbit mAb

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说明书下载
货号: PL0190
货期: 现货
价格: 100μL/1800
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靶点: LATS2
应用: WB,IF,ELISA
反应性 : Human
宿主物种 : Rabbit
MW(CalcμLated) : 120kD
MW(Observed): 130kD
同种型-Isotype : IgG,Kappa

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆号 : Monoclonal

抗原&靶点信息

特异性 : Endogenous
基因名称 : LATS2
蛋白名称 : Serine/threonine-protein kinase LATS2
别名 : LATS2;KPM;Serine/threonine-protein kinase LATS2;Kinase phosphorylated during mitosis protein;Large tumor suppressor homolog 2;Serine/threonine-protein kinase kpm;Warts-like kinase

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008],

细胞定位 : Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.

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