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货号: PL0223
货期: 现货
价格: 100μL/1800
靶点: FGFR3
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 88kD
MW(Observed): 125kD
同种型-Isotype : IgG,Kappa
隐藏域元素占位
详细信息
推荐稀释比 : IHC 1:200-1:500;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆号 : Monoclonal
抗原&靶点信息
特异性 : Endogenous
基因名称 : FGFR3 JTK4
蛋白名称 : Fibroblast growth factor receptor 3
别名 : FGFR3;JTK4;Fibroblast growth factor receptor 3;FGFR-3;CD antigen CD333
背景:
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dys


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