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货号: PL0416
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: Tyk 2
应用： WB,IF,ELISA
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 134kD
MW(Observed)： 134kD
同种型-Isotype ： IgG,Kappa
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 ： Protein A
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
克隆号 ： PT1348R
抗原&靶点信息
特异性 ： Endogenous
基因名称 ： TYK2
蛋白名称 ： Non-receptor tyrosine-protein kinase TYK2
别名 ： TYK2;Non-receptor tyrosine-protein kinase TYK2
背景：
tyrosine kinase 2(TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],
细胞定位 ： Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also called autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. The syndrome consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.,Domain:The FERM domain mediates interaction with JAKMIP1.,Function:Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.,online information:TYK2 mutation db,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with JAKMIP1.,tissue specificity:Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.,
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