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CD74 Rabbit mAb

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说明书下载
货号: PL0580
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: CD74
应用: WB,IHC,IF,ELISA
反应性 : Human
宿主物种 : Rabbit
MW(CalcμLated) : 34kD
MW(Observed): 34kD
同种型-Isotype : IgG,Kappa

隐藏域元素占位

详细信息

推荐稀释比 : IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT1173R

抗原&靶点信息

特异性 : Endogenous
基因名称 : CD74
蛋白名称 : HLA class II histocompatibility antigen gamma chain
别名 : CD74;DHLAG;HLA class II histocompatibility antigen gamma chain;HLA-DR antigens-associated invariant chain;Ia antigen-associated invariant chain;Ii;p33;CD74

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],

细胞定位 : Function:Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Nonamer composed of three alpha/beta/gamma heterotrimers.,

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