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货号: PL1466
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: ZAP-70/Syk
应用： WB,IF,ELISA
反应性 ： Human,Mouse
宿主物种 ： Rabbit
MW(CalcμLated) ： 70kD
MW(Observed)： 70kD
同种型-Isotype ： IgG,Kappa
偶联-Conjugate ： Phospho
隐藏域元素占位
详细信息
修饰-Modification ： Tyr319/Tyr352
推荐稀释比 ： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 ： Protein A
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
克隆号 ： PT0710R
抗原&靶点信息
特异性 ： The antibody detects endogenous ZAP-70/Syk(Phospho AE13) protein.
基因名称 ： ZAP70/SYK
蛋白名称 ： Tyrosine-protein kinase ZAP-70/Tyrosine-protein kinase SYK
别名 ： ZAP70;SRK;Tyrosine-protein kinase ZAP-70;70 kDa zeta-chain associated protein;Syk-related tyrosine kinase;SYK;Tyrosine-protein kinase SYK;Spleen tyrosine kinase;p72-Syk;
数据库链接：
背景：
ZAP70 gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],SYK gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
细胞定位 ： Cytoplasm . Cell membrane ; Peripheral membrane protein . In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). cytosol .
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