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货号: PL1033
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: TRAF6
应用： WB,IHC,IF,ELISA
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 60kD
MW(Observed)： 60kD
同种型-Isotype ： IgG,Kappa
偶联-Conjugate ： Unmodified
隐藏域元素占位
详细信息
推荐稀释比 ： IHC 1:100-1:500;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 ： Protein A
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
克隆号 ： PT0707R
抗原&靶点信息
特异性 ： Endogenous
基因名称 ： TRAF6
蛋白名称 ： TNF receptor-associated factor 6
别名 ： TRAF6;RNF85;TNF receptor-associated factor 6;E3 ubiquitin-protein ligase TRAF6;Interleukin-1 signal transducer;RING finger protein 85
背景：
TNF receptor associated factor 6(TRAF6) Homo sapiens The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has
细胞定位 ： Cytoplasm . Cytoplasm, cell cortex . Nucleus . Lipid droplet . Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). .
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