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货号: PL1144
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: ErbB-3/her2
应用: WB,IF,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 148kD
MW(Observed): 185kD
同种型-Isotype : IgG,Kappa
偶联-Conjugate : Unmodified
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT0593R
抗原&靶点信息
特异性 : Endogenous
基因名称 : ERBB3,HER3
蛋白名称 : Receptor tyrosine-protein kinase erbB-3
别名 : ERBB3;HER3;Receptor tyrosine-protein kinase erbB-3;Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3
背景:
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m


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