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Raf-B (phospho Thr401) Rabbit mAb

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货号: PL1351
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: Raf-B
应用: WB,IHC,IF,IP,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 84kD
MW(Observed): 84kD
同种型-Isotype : IgG,Kappa
偶联-Conjugate : Phospho

隐藏域元素占位

详细信息

修饰-Modification : Thr401
推荐稀释比 : IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT0329R

抗原&靶点信息

特异性 : This antibody detects endogenous levels of Raf-B only when phosphorylated at Thr401.This antibody does not recognize phosphorylated at other sites.
基因名称 : BRAF
蛋白名称 : Serine/threonine-protein kinase B-raf
别名 : BRAF;BRAF1;RAFB1;Serine/threonine-protein kinase B-raf;Proto-oncogene B-Raf;p94;v-Raf murine sarcoma viral oncogene homolog B1

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008],

细胞定位 : Cytoplasm,Nucleus

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