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Glucocorticoid Receptor Rabbit mAb

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说明书下载
货号: PL1365
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: GR
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse,Rat,
宿主物种 : Rabbit
MW(CalcμLated) : 85kD
MW(Observed): 94kD
同种型-Isotype : IgG,Kappa
偶联-Conjugate : Unmodified

隐藏域元素占位

详细信息

推荐稀释比 : IHC 1:1000-1:4000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT0306R

抗原&靶点信息

特异性 : Endogenous
基因名称 : Nr3c1 Grl Grl1
蛋白名称 : Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)
别名 : NR3C1;GRL;Glucocorticoid receptor;GR;Nuclear receptor subfamily 3 group C member 1

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

细胞定位 : Nucleus

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